Expanded gene targeting in RNA hacking with G-tract-supply Staple oligomer
Tomoki Kida, Yua Hasegawa, Miko Kato, Mahiro Ohtani, Ayu Matsumoto, Ririka Taniguchi, Rinka Ohno, Hiroshi Sugiyama, Toshihiro Ihara, Masaki Hagihara, Shin‐ichi Sato, Yousuke Katsuda
This paper introduces Gs-Staple oligomers to expand RNAh's target range by alleviating sequence constraints, enabling broader mRNA targeting and precise gene suppression in mammalian cells and in vivo.
Angewandte Chemie International Edition · Feb 22, 2026Peer-reviewedBioengineering