Author

Yousuke Katsuda

Kumamoto UniversityORCID 0000-0002-5586-4530Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:multiome· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Masaki HagiharaiD· 2 shared Shin‐ichi SatoiD· 2 shared Tomoki KidaiD· 2 shared Toshihiro IharaiD· 2 shared Ayu MatsumotoiD· 1 shared Hiroshi SugiyamaiD· 1 shared Mahiro OhtaniiD· 1 shared Miko KatoiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBioengineering

Masaki HagiharaORCID

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2 papers

Recent·Most cited

Expanded gene targeting in RNA hacking with G-tract-supply Staple oligomer

Tomoki Kida, Yua Hasegawa, Miko Kato, Mahiro Ohtani, Ayu Matsumoto, Ririka Taniguchi, Rinka Ohno, Hiroshi Sugiyama, Toshihiro Ihara, Masaki Hagihara, Shin‐ichi Sato, Yousuke Katsuda

This paper introduces Gs-Staple oligomers to expand RNAh's target range by alleviating sequence constraints, enabling broader mRNA targeting and precise gene suppression in mammalian cells and in vivo.

Angewandte Chemie International Edition · Feb 22, 2026Peer-reviewedBioengineering

In Vivo mRNA Hacking with Staple Oligomers Prevents Myocardial Hypertrophy

Yousuke Katsuda, Takuto Kamura, Tomoki Kida, Takeru Saeki, Yua Itsuki, Yuri Kato, Taishi Nakamura, Motohiro Nishida, Yusuke Kitamura, Toshihiro Ihara, Masaki Hagihara, Shin‐ichi Sato

This paper introduces a method to suppress target protein translation by inducing RNA G-quadruplex structures using Staple oligomers, demonstrating efficacy in preventing cardiac hypertrophy in mice.

bioRxiv · Apr 18, 2023 · PreprintMolecular Biology