Hiroshi Sugiyama

This paper introduces Gs-Staple oligomers to expand RNAh's target range by alleviating sequence constraints, enabling broader mRNA targeting and precise gene suppression in mammalian cells and in vivo.

This paper introduces a chemical probe-based nanopore sequencing method to selectively assess RNA modifications like inosine and pseudouridine with single-nucleotide resolution.

This study uses DNA origami and fast-scan atomic force microscopy to visualize PKA activation at the single-molecule level by observing cAMP-induced dissociation of catalytic subunits.

The paper identifies a GGC repeat expansion in the NOTCH2NLC gene using long-read sequencing, linking it to neuronal intranuclear inclusion disease in both familial and sporadic cases.