Masaki Hagihara

This paper introduces Gs-Staple oligomers to expand RNAh's target range by alleviating sequence constraints, enabling broader mRNA targeting and precise gene suppression in mammalian cells and in vivo.

This paper introduces a method to suppress target protein translation by inducing RNA G-quadruplex structures using Staple oligomers, demonstrating efficacy in preventing cardiac hypertrophy in mice.