Multiple Epigenetic Mechanisms Functionally Cooperate to Silence Expression of Somatostatin Receptor Type 2 in Pancreatic Neuroendocrine Tumors
James P. Madigan, Stephen G. Andrews, Rivka B. Farrell, Steven D. Forsythe, Rupali Sharma, Michele Ceribelli, Craig J. Thomas, Kimia N Shamsian, Shinjen Lin, Ken Chih-Chien Cheng, Samira Mercedes Sadowski
This study identifies multiple epigenetic mechanisms that silence SSTR2 expression in PNETs, highlighting the role of DNMT3B, PRC complexes, histone demethylases, and chromatin remodelers, with potential therapeutic implications.
bioRxiv · Sep 23, 2025 · PreprintCancer Biology