Author

Rupali Sharma

National Institutes of HealthORCID 0000-0002-0733-1270Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

James P. MadiganiD· 2 shared Samira Mercedes SadowskiiD· 2 shared Bhargav EarlaiD· 1 shared Craig J. ThomasiD· 1 shared Freddy E. EscorciaiD· 1 shared Ken Chih-Chien ChengiD· 1 shared Kimia N Shamsian· 1 shared Kwamena E. BaidooiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

James P. MadiganORCID

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2 papers

Recent·Most cited

Multiple Epigenetic Mechanisms Functionally Cooperate to Silence Expression of Somatostatin Receptor Type 2 in Pancreatic Neuroendocrine Tumors

James P. Madigan, Stephen G. Andrews, Rivka B. Farrell, Steven D. Forsythe, Rupali Sharma, Michele Ceribelli, Craig J. Thomas, Kimia N Shamsian, Shinjen Lin, Ken Chih-Chien Cheng, Samira Mercedes Sadowski

This study identifies multiple epigenetic mechanisms that silence SSTR2 expression in PNETs, highlighting the role of DNMT3B, PRC complexes, histone demethylases, and chromatin remodelers, with potential therapeutic implications.

bioRxiv · Sep 23, 2025 · PreprintCancer Biology

Upregulation of Somatostatin Receptor Type 2 in a Receptor-Deficient In Vivo Pancreatic Neuroendocrine Tumor Model Improves Tumor Response to Targeted 177Lu-DOTATATE

Rupali Sharma, Bhargav Earla, Kwamena E. Baidoo, Martha A. Zeiger, James P. Madigan, Freddy E. Escorcia, Samira Mercedes Sadowski

This study shows that HDAC inhibitors increase SSTR2 expression in pancreatic neuroendocrine tumors, enhancing 177Lu-DOTATATE therapy efficacy in receptor-deficient models.

bioRxiv · Apr 25, 2022 · PreprintMolecular Biology