Prime Editing in Mice Reveals the Essentiality of a Single Base in Driving Tissue-Specific Gene Expression
Pan Gao, Qing Lyu, Amr R. Ghanam, Cícera Regina Lazzarotto, Gregory A. Newby, Wei Zhang, Mi‐Hyun Choi, Orazio J. Slivano, Kevin Holden, John A. Walker, Anastasia P. Kadina, Rob J. Munroe, Christian M. Abratte, John C. Schimenti, David R. Liu, , Joseph M. Miano
This paper compares CRISPR-mediated HDR and PE2 systems in mice to show PE2's higher fidelity in editing a TFBS, leading to more effective tissue-specific gene inactivation.
Genome biology · Mar 15, 2021Peer-reviewedGenetics