Qing Lyu

GRAFT predicts drug responses across cell types without direct measurements by transferring genetic perturbation data to chemical perturbations.

This study identifies sex-specific endothelial cell transdifferentiation trajectories in atherosclerosis, revealing distinct fates in males and females and a novel direct EC-to-adipocyte transition.

This paper introduces 3D-VirtualCM, a method to reconstruct full cardiomyocyte transcriptomes from spatial transcriptomic sections, revealing spatial and transcriptional heterogeneity in infarcted mouse hearts.

scJET generates full-gene single-cell expression matrices using a patch-based Transformer model, preserving global and local transcriptomic features.

This paper identifies INKILN, a human-specific lncRNA that promotes vascular smooth muscle inflammation by stabilizing MKL1 and interacting with USP10.

This paper compares two CreERT2 mice, showing Itga8-CreERT2 avoids a lethal intestinal phenotype seen with Myh11-CreERT2 when knocking out Srf.

This paper compares CRISPR-mediated HDR and PE2 systems in mice to show PE2's higher fidelity in editing a TFBS, leading to more effective tissue-specific gene inactivation.