TomoSegNet: Augmented membrane segmentation for cryo-electron tomography by simulating the cellular context
Rachida Seghiri, Juan Diego Gallego Nicolás, Robert Brandt, Miguel A. Meroño, Pierre Lefevre, Noushin Hajarolasvadi, Daniel Baum, Jessica Heebner, Harold Phelippeau, Pascal Doux, Antonio Martínez-Sánchez
TomoSegNet improves membrane segmentation in cryo-electron tomography by using synthetic data generated with a biophysical simulator, outperforming existing methods in recovering distorted membranes.
bioRxiv · Jan 16, 2026 · PreprintBioinformatics