Antonio Martínez-Sánchez

MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography

MemBrain v2 couples a generalist U-Net cryo-ET membrane segmenter, a mesh-based picker reaching 91% F1 for photosystem II from one annotated membrane, and geodesic particle statistics.

TomoSegNet: Augmented membrane segmentation for cryo-electron tomography by simulating the cellular context

TomoSegNet improves membrane segmentation in cryo-electron tomography by using synthetic data generated with a biophysical simulator, outperforming existing methods in recovering distorted membranes.

Spatial organization of assemblies of protein complexes by colocalization analysis

The paper introduces a parameter-free method for analyzing colocalization in cryo-electron tomograms to study spatial organization of protein complexes.

DeepOrientation: Deep Orientation Estimation of Macromolecules in Cryo-electron tomography

This paper introduces a deep learning model for orientation estimation of macromolecules in cryo-ET images using synthetic data and shows promising results.

Simulating the cellular context in synthetic datasets for cryo-electron tomography

This paper introduces synthetic datasets for cryo-electron tomography to train deep learning algorithms by simulating cellular structures and geometries.

MemBrain: A Deep Learning-aided Pipeline for Automated Detection of Membrane Proteins in Cryo-electron Tomograms

MemBrain detects membrane proteins in cryo-ET data using a deep learning pipeline, achieving high accuracy with minimal labels and generalizing across different cell types and imaging methods.

Deep Learning Improves Macromolecule Identification in 3D Cellular Cryo-Electron Tomograms

This paper introduces DeepFinder, a deep learning method that improves macromolecule identification in 3D cellular cryo-ET data by localizing multiple species with high accuracy.

Trans-synaptic assemblies link synaptic vesicles and neuroreceptors

The paper uses cryo-electron tomography to visualize trans-synaptic assemblies linking synaptic vesicles and receptors, showing their precise organization and structure.

The Structural Basis of Rubisco Phase Separation in the Pyrenoid

This study identifies the structural basis of Rubisco phase separation in the pyrenoid by analyzing interactions between Rubisco and its linker protein EPYC1 in Chlamydomonas reinhardtii.

Estimation of Membrane Curvature for Cryo-Electron Tomography

The paper develops a method to estimate membrane curvature from cryo-ET data, showing its validity on benchmark surfaces and application to biological data.