Metallothionein loss in cancer cells contributes to increased mutations through defective DNA repair and metabolic imbalance
Mirna Mina-Abouda, Amy C. Rees, Della R. Evans, Evan D. Villamor, George Fullbright, Heather R. Ghent, Madison A. Clark, Wendy Y Zhang, Isabel Koehler, Isabella Berry, Sydney Oesch, Robert Hutchinson, Davide Delisi, Christopher de Solis, Alexander Y. Maslov, , Joe Ryan Delaney
This study shows that loss of metallothionein (MT) in cancer cells increases mutations by impairing DNA repair and causing metabolic imbalance.
bioRxiv · Aug 12, 2026 · PreprintCancer Biology