MicrobiologybioRxivPreprint
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice
Yousef M. Alhammad, Srivatsan Parthasarathy, Roshan Ghimire…·Anthony R. Fehr
This study shows that SARS-CoV-2 Mac1 is essential for pathogenesis but not replication, as Mac1-deleted virus replicates normally but induces higher IFN responses and reduced disease in mice.
DOI 10.1101/2023.04.06.535927