Robert L. Unckless

This study investigates the tissue and cellular tropism of Drosophila innubila Nudivirus in cultured cells and infected hosts, finding that the virus localizes to the nucleus in cells and the gut and reproductive tissues in hosts.

The paper identifies RNA viruses and transposable elements in Drosophila using single-nucleus transcriptomics, revealing tissue-specific viral tropism and TE expression patterns.

This study identifies Atg8/LC3 as a stress-responsive chromatin cofactor that coordinates immune and metabolic transcription through interactions with NF-κB/Dif in Drosophila.

The paper examines transcriptional changes in Drosophila fat body cells during persistent viral infections using snRNA-seq data, revealing immune pathway activation and transposable element dysregulation.

The paper reconstructs the evolutionary history of the Drosophila pseudoobscura Sex-Ratio chromosome, showing it has undergone cycles of drive, suppression, and escape from suppression, with current lack of suppression being a transient state.

This paper develops a DiNV model system for studying DNA virus-host interactions in Drosophila by creating cell lines, assays, and infection protocols.

This study identifies Drosophila cell lines that support replication of Drosophila innubila Nudivirus and shows that a cell culture-adapted strain can infect broadly and produce infectious virions.

The paper investigates the role of TRKIN in maize meiotic drive, finding it to be deleterious when paired with normal chromosomes and suggesting it is being purged from populations.

The paper compares methods for assessing pathogenicity using Drosophila and Providencia bacteria, highlighting advantages and limitations of different statistical approaches.

This study uses simulations to show that autosomal suppressors can block the invasion of Y-linked suppressors and prevent cyclic dynamics in sex chromosome evolution.

This study shows that a single amino acid polymorphism in the Drosophila AMP Mtk affects systemic immunity and life history traits differently in males and females.

The paper examines genetic variation in immune defense against Lysinibacillus fusiformis in three Drosophila populations, finding little overlap in genetic architecture but shared QTL for resistance to two pathogens.

The paper examines how DCC binding affects gene expression changes on the X chromosome in Drosophila under various treatments, finding that DCC-bound genes are less likely to be up- or down-regulated.

The paper identifies ETR-1/CELF1 RNA targets in C. elegans body wall muscle, revealing roles in muscle physiology and neuronal migration.

The paper examines the genome and population genomics of a male-killing Wolbachia strain, identifying rapid evolution and horizontal gene transfer in specific regions.

The paper compares transcriptional responses to bacterial pathogens in Drosophila and Caenorhabditis, finding conserved and divergent gene expression patterns.

This paper introduces a deep learning method for detecting copy number variants in short-read sequencing data, showing improved performance over traditional methods in low coverage data.

The paper sequences the genome of Drosophila innubila and finds that antiviral RNAi genes evolve slowly, contrasting with Drosophila melanogaster, suggesting different evolutionary pressures for DNA and RNA virus resistance.

This paper sequences and analyzes the genome of Drosophila innubila nudivirus, identifying adaptation signatures and gene turnover patterns in its evolution.

The paper models the Mutagenic Chain Reaction (MCR) as a meiotic drive mechanism, showing that an introduced allele can invade a population only if its frequency exceeds a critical threshold, even when it has a fitness cost.

The paper analyzes the probability of evolutionary rescue from sex-ratio meiotic drive, showing that extinction risk depends on drive strength, sex ratio skew, and suppressor dynamics.