Direct Visualization of Protein Kinase A Activation on DNA Origami using Fast-Scan Atomic Force Microscopy
Ioanna Mela, Daniel Ladant, Hiroshi Sugiyama, Masayuki Endo, John Michael Edwardson, Robert M. Henderson
This study uses DNA origami and fast-scan atomic force microscopy to visualize PKA activation at the single-molecule level by observing cAMP-induced dissociation of catalytic subunits.
bioRxiv · Sep 7, 2020 · PreprintMolecular Biology