Ioanna Mela

Programmable DNA-peptide nanostructures for multivalent regulation of intracellular signalling

This paper develops DNA-peptide nanostructures to multivalently inhibit TNKS, showing they effectively downregulate Wnt signaling in cancer cells despite differences in TBP copy number.

DNA aptamers to interfere with HasA, the hemophore of the heme assimilation system in Pseudomonas aeruginosa, as a potential antimicrobial strategy

This paper identifies DNA aptamers that bind the truncated form of HasA, a hemophore in Pseudomonas aeruginosa, under acidic conditions, showing potential as antimicrobial agents.

A generalisable method for the purification and biophysical characterisation of bacterial membrane receptors

This paper describes a method to purify and characterize soluble domains of bacterial membrane receptors, demonstrating its effectiveness with the HasR receptor from Pseudomonas aeruginosa.

A facile and reproducible method for the purification of peptide- and protein-functionalized DNA nanostructures

This paper introduces a fast and efficient purification method for peptide- and protein-functionalized DNA nanostructures with high yield and purity.

Local ionic conditions modulate the aggregation propensity and influence the structural polymorphism of alpha-synuclein

This study investigates how Ca2+ and Na+ ions affect alpha-synuclein aggregation and fibril polymorphism, revealing their distinct roles in modulating conformational dynamics and structural outcomes.

Mutation of the ALS/FTD-associated RNA-binding protein FUS alters axonal cytoskeletal organisation

The paper investigates how mutations in the FUS protein affect axonal cytoskeletal organisation in ALS/FTD models, finding reduced actin density and axonal branch complexity.

α-synuclein fibril and synaptic vesicle interactions lead to vesicle destruction and increased uptake into neurons

This study investigates how monomeric and fibrillar alpha-synuclein interact with synaptic vesicles, showing fibrils disintegrate vesicles and increase neuronal uptake, potentially contributing to Parkinson's disease pathology.

Design of Biologically Active Binary Protein 2D Materials

The paper designs binary 2D protein co-assemblies that form ordered, biologically active materials with potential therapeutic applications.

Direct Visualization of Protein Kinase A Activation on DNA Origami using Fast-Scan Atomic Force Microscopy

This study uses DNA origami and fast-scan atomic force microscopy to visualize PKA activation at the single-molecule level by observing cAMP-induced dissociation of catalytic subunits.