Daniel Ladant

This study investigates the translocation mechanisms of two CyaA-derived peptides, showing that P454 translocates independently of membrane potential while P233 requires a negative potential, and their covalent linkage enables translocation without potential.

This paper describes a method to detect protein-protein interactions in living bacteria with single molecule sensitivity using a synthetic adenylate cyclase system.

This study designs peptides targeting the FtsQBL divisome complex in E. coli using structure-guided methods, showing they inhibit cell division.

The paper investigates how ExoY-catalyzed cGMP modulates ExoT cytotoxicity and reveals reciprocal interactions between T3SS effectors in P. aeruginosa infections.

This study shows that acylation stabilizes the native fold of CyaA and facilitates its membrane orientation, revealing how post-translational modification drives toxin activity.

This study uses DNA origami and fast-scan atomic force microscopy to visualize PKA activation at the single-molecule level by observing cAMP-induced dissociation of catalytic subunits.

The paper shows that actin activates ExoY and ExoY-like cyclases from pathogens, revealing a new class of actin-activated nucleotidyl cyclase toxins.