Improving peptide vaccine manufacturability without sacrificing immunogenicity: substitution of methionine and cysteine with oxidation-resistant isosteres
Andrew S. Ishizuka, Christopher M. Garliss, Robert N. Goddu, Maria I. Merolle, Alec Schrager, Andrei Ramirez-Valdez, Qiuyin Ren, Faezzah Baharom, Matthew Essandoh, Nicholas G Palacorolla, John P. Finnigan, Daniel C. Douek, Nina Bhardwaj, Robert A. Seder, Geoffrey M. Lynn, David R. Wilson
This study introduces oxidation-resistant (OXR) antigens by substituting cysteine and methionine with isosteres to improve peptide vaccine manufacturability without compromising immunogenicity.
The Journal of Immunology · Aug 29, 2026Peer-reviewedImmunology