Nina Bhardwaj

This study introduces oxidation-resistant (OXR) antigens by substituting cysteine and methionine with isosteres to improve peptide vaccine manufacturability without compromising immunogenicity.

This study identifies the role of mature dendritic cells type 1 in forming, maintaining, and functioning tertiary lymphoid structures in cancer.

This study identifies T cell and macrophage subsets that mediate response to anti-PD-1 therapy in colorectal cancer, showing that combination therapy can eradicate tumors in both MMRd and MMRp settings.

This study identifies conserved neoantigens across species and tissues that elicit strong immune responses and suppress tumor growth through vaccination.

The paper maps T cell epitopes in SARS-CoV-2, showing that immunodominant regions are conserved across variants and important for immune surveillance.

This study identifies SLAMF6 signaling suppression in bladder cancer tumor microenvironment as a cause of NK cell dysfunction, showing restoration of function under normoxic conditions.

This paper shows that AXL inhibits cholesterol mobilization in dendritic cells, which is necessary for their maturation and immunogenic response to cancer.

FAUST is a new interpretable machine learning method for single-cell cytometry that discovers and validates T cell correlates of response to anti-PD-1 immunotherapy.

The paper identifies proinflammatory monocytes/macrophages associated with resistance to PD-1/PD-L1 blockade in urothelial cancer using bulk and single-cell RNA sequencing.

This study maps immune cell transcriptional profiles in human and mouse bladder tumors to identify conserved and divergent gene expression patterns and immune cell interactions.

The paper describes a computational pipeline for a personalized neoantigen vaccine trial, including tools for variant calling, peptide selection, and sequence reconstruction.