Author

Geoffrey M. Lynn

National Institutes of HealthORCID 0000-0001-9653-6691Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrei Ramirez-Valdez· 2 shared Andrew S. IshizukaiD· 2 shared Christopher M. GarlissiD· 2 shared Robert A. SederiD· 2 shared Alec Schrager· 1 shared Benjamin Louis SieversiD· 1 shared Dalton HermansiD· 1 shared Daniel C. DouekiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Andrei Ramirez-Valdez

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Improving peptide vaccine manufacturability without sacrificing immunogenicity: substitution of methionine and cysteine with oxidation-resistant isosteres

Andrew S. Ishizuka, Christopher M. Garliss, Robert N. Goddu, Maria I. Merolle, Alec Schrager, Andrei Ramirez-Valdez, Qiuyin Ren, Faezzah Baharom, Matthew Essandoh, Nicholas G Palacorolla, John P. Finnigan, Daniel C. Douek, Nina Bhardwaj, Robert A. Seder, Geoffrey M. Lynn, David R. Wilson

This study introduces oxidation-resistant (OXR) antigens by substituting cysteine and methionine with isosteres to improve peptide vaccine manufacturability without compromising immunogenicity.

The Journal of Immunology · Aug 29, 2026Peer-reviewedImmunology

Spatiotemporal dynamics of adoptively transferred stem-like CD8+ T cells in the tumor microenvironment following vaccination

Dalton Hermans, Sloane Christian Fussell, Andrei Ramirez-Valdez, Sam Shepard, Remi Poulard, Sonia Zumalave, Benjamin Louis Sievers, Christopher M. Garliss, Vincent L. Coble, Geoffrey M. Lynn, Andrew S. Ishizuka, Isidro Cortés‐Ciriano, Robert A. Seder

This study shows that stem-like CD8+ T cells, when used in adoptive cell therapy followed by vaccination, improve tumor control by altering the tumor microenvironment's transcriptomic profile.

bioRxiv · May 14, 2026 · PreprintImmunology