A Mechanism Based Pharmacokinetic/Pharmacodynamic Analysis of Polymyxin B-Based Combination Therapy Against Carbapenem-Resistant Klebsiella pneumoniae Isolates with Diverse Phenotypic and Genotypic Resistance Mechanisms
Ramya Mahadevan, Estefany Garcia, Rajnikant Sharma, Hongqiang Qiu, Ahmed Elsheikh, Robert Parambi, Cely Saad Abboud, Fernando G. Pasterán, María Soledad Ramirez, Keith S. Kaye, Robert A. Bonomo, Gauri G. Rao
This study develops a mechanism-based pharmacokinetic/pharmacodynamic model to evaluate PMB-based combination therapy against CRKP, showing synergistic effects with lower PMB doses.
Antimicrobial Agents and Chemotherapy · Dec 19, 2025Peer-reviewedPharmacology & Toxicology