Author

María Soledad Ramirez

California State University, FullertonORCID 0000-0002-9904-7890Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Fernando G. PasterániD· 3 shared Marcelo E. TolmaskyiD· 3 shared Robert A. BonomoiD· 3 shared Alejandra C. CorsoiD· 2 shared Gauri G. RaoiD· 2 shared German Matias TragliaiD· 2 shared Vyanka MezcordiD· 2 shared Ahmed Elsheikh· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersMicrobiology

Fernando G. PasteránORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Pharmacology & ToxicologyAntimicrobial Agents and ChemotherapyPeer-reviewedDec 19, 2025

A Mechanism Based Pharmacokinetic/Pharmacodynamic Analysis of Polymyxin B-Based Combination Therapy Against Carbapenem-Resistant Klebsiella pneumoniae Isolates with Diverse Phenotypic and Genotypic Resistance Mechanisms

Ramya Mahadevan, Estefany Garcia, Rajnikant Sharma…·Gauri G. Rao

This study develops a mechanism-based pharmacokinetic/pharmacodynamic model to evaluate PMB-based combination therapy against CRKP, showing synergistic effects with lower PMB doses.

5 citations

humanstatistical model

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MicrobiologyJournal of Global Antimicrobial ResistancePeer-reviewedJul 15, 2025

Emerging Resistance to Novel -βLactam β-Lactamase Inhibitor Combinations in Klebsiella pneumoniae bearing KPC Variants

Mase Hamza, German Matias Traglia, Lucía Maccari…·Maria Soledad Ramirez

This study identifies emerging resistance in KPC variants of K. pneumoniae to CZA, FDC, and FPZ, with mutations in specific regions linked to collateral resistance.

21 citationstop 2%

bacteria (other)experimental assay

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MicrobiologyMicrobiology SpectrumPeer-reviewedAug 20, 2024

Hetero-antagonism of avibactam and sulbactam with cefiderocol in carbapenem-resistant Acinetobacter spp.

Olivia Wong, Vyanka Mezcord, Christina Lopez…·María Soledad Ramirez

This study investigates the molecular mechanisms of cefiderocol resistance and antagonism with avibactam and sulbactam in carbapenem-resistant Acinetobacter strains.

5 citations

humanexperimental assay

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BiochemistryAntibioticsPeer-reviewedJul 19, 2024

Structure-activity relationship of pyrrolidine pentamine derivatives as inhibitors of the aminoglycoside 6'-N-acetyltransferase type Ib

Jan Sklenicka, Tung Tran, María Soledad Ramirez…·Marcelo E. Tolmasky

This study identifies pyrrolidine pentamine derivatives as inhibitors of AAC(6')-Ib, showing that structural modifications affect inhibitory activity and that molecular docking correlates with potency.

7 citations

statistical modeldrug response / drug discovery

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