Author

Rajnikant Sharma

University of Southern CaliforniaORCID 0000-0002-0891-7548Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Gauri G. RaoiD· 2 shared Ramya MahadevaniD· 2 shared Ahmed Elsheikh· 1 shared Alan A. SchmalstigiD· 1 shared Anthony James HickeyiD· 1 shared Cely Saad AbboudiD· 1 shared ChunFu Cheng· 1 shared Estefany GarciaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPharmacology & Toxicology

Gauri G. RaoORCID

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2 papers

Recent·Most cited

Pharmacokinetics and Physiologically Based Pharmacokinetic Modeling of Mycobacteriophages: Insights into Pulmonary Distribution and Clearance

Rajnikant Sharma, Ramya Mahadevan, Sai Divyash, Shekhar Yeshwante, Saikumar Matcha, ChunFu Cheng, Hunter S. Talley, Alan A. Schmalstig, Pradeep Neupane, Sara E. Maloney, Anthony James Hickey, Graham F. Hatfull, Miriam Braunstein, Gauri G. Rao

The paper studies pharmacokinetics of mycobacteriophages in mice and develops a PBPK model to predict their distribution and clearance, showing that inhalation improves lung exposure.

Molecular Pharmaceutics · Sep 17, 2026Peer-reviewedPharmacology & Toxicology

A Mechanism Based Pharmacokinetic/Pharmacodynamic Analysis of Polymyxin B-Based Combination Therapy Against Carbapenem-Resistant Klebsiella pneumoniae Isolates with Diverse Phenotypic and Genotypic Resistance Mechanisms

Ramya Mahadevan, Estefany Garcia, Rajnikant Sharma, Hongqiang Qiu, Ahmed Elsheikh, Robert Parambi, Cely Saad Abboud, Fernando G. Pasterán, María Soledad Ramirez, Keith S. Kaye, Robert A. Bonomo, Gauri G. Rao

This study develops a mechanism-based pharmacokinetic/pharmacodynamic model to evaluate PMB-based combination therapy against CRKP, showing synergistic effects with lower PMB doses.

Antimicrobial Agents and Chemotherapy · Dec 19, 2025Peer-reviewedPharmacology & Toxicology