Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE
Yaqi Liu, Chelsea M. Brown, Nuno Borges, Rodrigo N. Nobre, Satchal K. Erramilli, Meagan Belcher Dufrisne, Brian Kloss, Sabrina I. Giacometti, Ana M. Esteves, Cristina G. Timóteo, Piotr Tokarz, Rosemary J. Cater, Todd L. Lowary, Yasu S. Morita, Anthony A. Kossiakoff, , Filippo Mancia
This study determines the cryo-EM structures of PimE from Mycobacterium abscessus and elucidates its mechanism of action, providing insights for anti-TB drug development.
Nature Communications · Apr 29, 2025Peer-reviewedBiochemistry