Author

Sabrina I. Giacometti

Columbia University Irving Medical CenterORCID 0000-0002-8291-7722Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:E. coli· 1 Approach:statistical model· 1

Frequent Co-Authors

Ana M. Esteves· 1 shared Anthony A. KossiakoffiD· 1 shared Brian KlossiD· 1 shared Chelsea M. BrowniD· 1 shared Cristina G. TimóteoiD· 1 shared Damian C. EkiertiD· 1 shared Filippo ManciaiD· 1 shared Gira BhabhaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

Ana M. Esteves

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2 papers

Recent·Most cited

Interactions of outer membrane lipoproteins P. aeruginosa PA3214 and E. coli PqiC with their MCE protein binding partners, PA3213 and PqiB

Sabrina I. Giacometti, Nicolas Coudray, Rachel L. Redler, Gira Bhabha, Damian C. Ekiert

The paper reports cryo-EM structures of P. aeruginosa PA3214 and E. coli PqiC lipoproteins interacting with their MCE protein partners, revealing their assembly and functional interactions.

Journal of Biological Chemistry · Aug 25, 2026Peer-reviewedMicrobiology

Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE

Yaqi Liu, Chelsea M. Brown, Nuno Borges, Rodrigo N. Nobre, Satchal K. Erramilli, Meagan Belcher Dufrisne, Brian Kloss, Sabrina I. Giacometti, Ana M. Esteves, Cristina G. Timóteo, Piotr Tokarz, Rosemary J. Cater, Todd L. Lowary, Yasu S. Morita, Anthony A. Kossiakoff, , Filippo Mancia

This study determines the cryo-EM structures of PimE from Mycobacterium abscessus and elucidates its mechanism of action, providing insights for anti-TB drug development.

Nature Communications · Apr 29, 2025Peer-reviewedBiochemistry