Todd L. Lowary

Discoidins are cytosolic lectins that recognize methylated L-rhamnose epitopes on mycobacterial glycolipids and glycopeptidolipids upon vacuole damage

Novel human monoclonal antibodies with enhanced sensitivity for lipoarabinomannan antigens present in urines of TB patients

Converting human antibody A194-01 from IgG1 to IgM broadens glycan recognition and boosts urinary lipoarabinomannan detection, and RU95-C1, a mannan-targeting antibody, works as a capture partner.

Biological recognition of mirror-image glycans

The paper evaluates how glycan-binding proteins and immune cells recognize mirror-image glycans, finding widespread binding and donor-specific recognition of L-glycans.

A Type VII-secreted toxin enables inter-mycobacterial competition

The paper identifies a type VII-secreted toxin in mycobacteria that enables inter-bacterial competition by targeting arabinogalactan.

Cell wall arabinogalactan is responsible for Fungitell(R) cross reactivity in nocardiosis

The paper identifies nocardial cell wall arabinogalactan as the cause of Fungitell(R) cross-reactivity in nocardiosis and shows that {beta}-glucose substitution in the galactan domain is responsible.

Evaluation of Multiplexed Liquid Glycan Array (LiGA) for Serological Detection of Glycan-binding Antibodies

This paper evaluates the multiplexed liquid glycan array (LiGA) for detecting ABO blood group antibodies in human serum, identifying its strengths and limitations.

Structural insights into terminal arabinosylation biosynthesis of the mycobacterial cell wall arabinan

This study presents cryo-EM structures of AftB from Mycobacterium chubuense, revealing its architecture and mechanism for terminal arabinosylation in mycobacterial cell wall biosynthesis.

Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE

This study determines the cryo-EM structures of PimE from Mycobacterium abscessus and elucidates its mechanism of action, providing insights for anti-TB drug development.