Specific oncogene activation of the cell of origin in mucosal melanoma
Swathy Babu, Jiajia Chen, Chloé S. Baron, Kaiwen Sun, Emily J. Robitschek, Alicia M. McConnell, Constance Wu, Aikaterini Dedeilia, Moshe Sade-Feldman, Rodsy Modhurima, Michael P. Manos, Kevin Y. Chen, Anna M. Cox, Calvin G. Ludwig, M. Kellis, , Megan L. Insco
This study develops a zebrafish model of mucosal melanoma by activating an oncogene and inactivating tumor suppressors, revealing that internal melanocytes give rise to tumors with distinct transcriptional and chromatin features.
Nature Communications · Jul 22, 2025Peer-reviewedCancer Biology