Author

Emily J. Robitschek

Broad InstituteORCID 0000-0002-2771-0155Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Organism:human· 2 Assay:ATAC-seq· 1 Approach:benchmark study· 1

Frequent Co-Authors

Amy Y. HuangiD· 3 shared David LiuiD· 3 shared Genevieve Marie BolandiD· 3 shared Jiekun YangiD· 3 shared Manolis KellisiD· 3 shared Arlene H. SharpeiD· 2 shared Cassia Wang· 2 shared Doris FuiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Amy Y. HuangORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Harnessing Inflammatory Monocytes to Overcome Resistance to Anti-PD-1 Immunotherapy

Matthew P. Zimmerman, Amy Y. Huang, Emily K. Cox, Rose Al Abosy, Wan Lin Chong, Alex Bastian, Katherine J. Vietor, Yacine A. Choutri, Jenna L. Collier, Vasyl Zhabotynsky, Haiyang Wang, Megan E. Fung, Sarah A. Weiss, Emily J. Robitschek, Jia‐Ren Lin, , Brian C. Miller

This study shows CD40 agonist therapy reduces tumor growth in antigen presentation-deficient tumors by reprogramming monocytes and requiring IFN-gamma and CD8+ T cells for efficacy.

bioRxiv · Feb 8, 2026 · PreprintImmunology

Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma

Jiekun Yang, Cassia Wang, Doris Fu, Li‐Lun Ho, Kyriakitsa Galani, Lee Chen, Jose Gonzalez, Jolene Yin Ling Fu, Amy Y. Huang, Dennie Tompers Frederick, Liang He, Mukta Asnani, Rahul Tacke, Emily J. Robitschek, Sandeep K. Yadav, , Manolis Kellis

The paper identifies a mature dendritic cell subtype associated with improved immune response and prognosis in melanoma patients treated with anti-PD-1 checkpoint inhibitors.

Nature Communications · Sep 1, 2025Peer-reviewedCancer Biology

Specific oncogene activation of the cell of origin in mucosal melanoma

Swathy Babu, Jiajia Chen, Chloé S. Baron, Kaiwen Sun, Emily J. Robitschek, Alicia M. McConnell, Constance Wu, Aikaterini Dedeilia, Moshe Sade-Feldman, Rodsy Modhurima, Michael P. Manos, Kevin Y. Chen, Anna M. Cox, Calvin G. Ludwig, M. Kellis, , Megan L. Insco

This study develops a zebrafish model of mucosal melanoma by activating an oncogene and inactivating tumor suppressors, revealing that internal melanocytes give rise to tumors with distinct transcriptional and chromatin features.

Nature Communications · Jul 22, 2025Peer-reviewedCancer Biology

Stratified analysis identifies HIF-2α as a therapeutic target for highly immune-infiltrated melanomas

Amy Y. Huang, Kelly P. Burke, Ryan M. Porter, Lynn Meiger, Peter R. Fatouros, Jiekun Yang, Emily J. Robitschek, Natalie I. Vokes, Cora A. Ricker, Valeria Rosado, Giuseppe Tarantino, Jiajia Chen, Tyler J. Aprati, Marc Glettig, Yiwen He, , David Liu

The paper identifies HIF-2α as a therapeutic target for immune-infiltrated melanomas through stratified analysis of clinical and molecular data.

bioRxiv · Oct 29, 2024 · PreprintCancer Biology