Jiajia Chen

Recurrent oncogenic ZC3H18 mutations stabilize endogenous retroviral RNA

This study identifies ZC3H18 mutations that stabilize endogenous retroviral RNA, linking ERV RNA accumulation to oncogenesis in zebrafish and human cell lines.

Loss of the tumor suppressor PTEN activates cell-intrinsic interferon signaling to drive immune resistance

This study shows that PTEN loss in cancer cells activates intrinsic interferon signaling, leading to immune resistance and vulnerability to CDK12 inhibition.

Specific oncogene activation of the cell of origin in mucosal melanoma

This study develops a zebrafish model of mucosal melanoma by activating an oncogene and inactivating tumor suppressors, revealing that internal melanocytes give rise to tumors with distinct transcriptional and chromatin features.

Stratified analysis identifies HIF-2α as a therapeutic target for highly immune-infiltrated melanomas

The paper identifies HIF-2α as a therapeutic target for immune-infiltrated melanomas through stratified analysis of clinical and molecular data.