Disentangling Schwann Cell and Neuronal TRPA1 Function in Mouse Models of Familial Episodic Pain Syndrome
Matilde Marini, Martina Chieca, Elisabetta Coppi, Marco Montini, Lorenzo Bonacchi, Lorenzo Landini, Irene Scuffi, Kelvin Y. Kwan, Alice Papini, Gaetano De Siena, Elisa Bellantoni, Lucrezia Timotei, Valentina Albanese, Gabriele Ferroni, Evelynn Dalila do Nascimento Melo, , Francesco De Logu
This study investigates the cell-specific roles of mutant TRPA1 in FEPS using mouse models, showing distinct contributions of neuronal and Schwann cell TRPA1 to pain mechanisms.
bioRxiv · Feb 17, 2026 · PreprintGenetics