Matilde Marini

Schwann cell p75NTR sustains persistent pain downstream to NGF through ROS-dependent TRPA1 signaling

The paper identifies a Schwann cell p75NTR-ROS-TRPA1 pathway that sustains persistent pain downstream of NGF, highlighting non-neuronal p75NTR signaling as a therapeutic target.

Triptans reprogram Schwann cells to drive medication-overuse headache via β-glycan/TGF-β3 signaling

This study identifies Schwann cell 5-HT1B/D signaling as a dual mediator of triptan efficacy and medication-overuse headache via TGF-β3-driven proalgesic pathways.

Disentangling Schwann Cell and Neuronal TRPA1 Function in Mouse Models of Familial Episodic Pain Syndrome

This study investigates the cell-specific roles of mutant TRPA1 in FEPS using mouse models, showing distinct contributions of neuronal and Schwann cell TRPA1 to pain mechanisms.

Targeting the Schwann Cell EP2/cAMP Nanodomain to Block Pain but not Inflammation

The paper identifies a druggable EP2 receptor in Schwann cells that encodes PG-mediated persistent inflammatory pain without affecting protective inflammation.