Schwann cell p75NTR sustains persistent pain downstream to NGF through ROS-dependent TRPA1 signaling
Matilde Marini, Alice Papini, Martina Chieca, Elisa Bellantoni, Giovanna Pivotto, Lucrezia Timotei, Gaetano De Siena, Maryam Raeispour, Alexandra Dimitrova, Lorenzo Bonacchi, Gabriele Ferroni, Irene Scuffi, Natália Gabriele Hösch, Sabrina Qader Kudsi, Francesco De Logu, Romina Nassini
The paper identifies a Schwann cell p75NTR-ROS-TRPA1 pathway that sustains persistent pain downstream of NGF, highlighting non-neuronal p75NTR signaling as a therapeutic target.
bioRxiv · Aug 20, 2026 · PreprintNeuroscience