Kelvin Y. Kwan

This study investigates the cell-specific roles of mutant TRPA1 in FEPS using mouse models, showing distinct contributions of neuronal and Schwann cell TRPA1 to pain mechanisms.

This study identifies glyco-modified RNAs in exosomes, showing their role in intercellular communication and suggesting a link between protein and RNA glycosylation.

This study identifies CHD7 binding sites in the Sox11 locus and shows how CHD7 regulates neuronal differentiation through chromatin remodeling and CTCF-marked insulators.

The paper shows CHD7 binds to insulator regions during neuronal differentiation, regulating gene expression through interactions with CTCF.

This study shows that CHD4 regulates axon guidance in spiral ganglion neurons by modulating chromatin at cis-regulatory elements to control axon guidance molecules.

The paper investigates the impact of the NLGN3 R451C mutation on human neurons, finding it reduces protein levels but enhances excitatory synapses, potentially contributing to ASD pathogenesis.

This study shows that KCNJ6 noncoding variants increase excitability in human glutamatergic neurons, an effect reversed by ethanol exposure.

The paper identifies Xrn1 as a deNADding enzyme in yeast that modulates mitochondrial NAD levels by releasing NAD from NAD-capped RNAs.

This study xenotransplants human PSC-derived microglia into mice to create a chimeric brain model that retains human microglial identity and exhibits disease-relevant responses.