Extrinsic polarity cues control lamination versus cluster-based organisation in vertebrate retinal development
Christina Schlagheck, Xenia Podlipensky, Cassian Afting, Ronald Curticean, Irene U. Wacker, Rasmus R. Schröder, Venera Weinhardt, Lucie Žílová, Joachim Wittbrodt
This study shows that extrinsic polarity cues determine whether retinal organoids develop a laminated epithelium or cluster-based organization, revealing plasticity in vertebrate retinal development.
iScience · May 15, 2026Peer-reviewedDevelopmental Biology