Lucie Žílová

The paper maps heterochrony in zebrafish and medaka using single-cell genomics, revealing cell-level timing shifts that contribute to species-specific phenotypes.

This study shows that extrinsic polarity cues determine whether retinal organoids develop a laminated epithelium or cluster-based organization, revealing plasticity in vertebrate retinal development.

This paper uses deep learning to predict tissue outcomes in retinal organoids before they are visually discernible, improving understanding of developmental trajectories.

This study generates fish ocular organoids with lens and retina, showing lens forms via an 'inside-out' process instead of the in vivo 'outside-in' mode.

This paper develops a multimodal approach combining X-ray computed tomography and light-sheet fluorescence microscopy to visualize gene expression in 3D tissue context, applicable to in vitro models and model organisms.

The paper shows fish-derived organoids rapidly self-organize into retinal tissue, mimicking in vivo eye development, and highlights the impact of cell number and genetics on morphogenesis.