Venera Weinhardt

Extrinsic polarity cues control lamination versus cluster-based organisation in vertebrate retinal development

This study shows that extrinsic polarity cues determine whether retinal organoids develop a laminated epithelium or cluster-based organization, revealing plasticity in vertebrate retinal development.

Decoding acute neuroinflammatory states from the 3D architecture of in vitro microglia

The paper decodes acute neuroinflammatory states in mouse microglia by analyzing their 3D cellular architecture and links lipid-endosome reorganization to the mTORC1 pathway.

Interior soft x-ray tomography with sparse global sampling

This paper develops a sparse reconstruction algorithm for soft X-ray tomography to achieve high spatial resolution and whole-cell imaging with reduced radiation dose.

Soft X-ray tomography reveals variations in B.subtilis biofilm structure upon tasA deletion

This paper uses soft X-ray tomography to analyze B.subtilis biofilm structure, showing structural changes in a tasA deletion mutant and the effect of TasA protein addition.

Visualisation of gene expression within the context of tissues: an X-ray computed tomography-based multimodal approach

This paper develops a multimodal approach combining X-ray computed tomography and light-sheet fluorescence microscopy to visualize gene expression in 3D tissue context, applicable to in vitro models and model organisms.

Fish primary embryonic stem cells self-assemble into retinal tissue mirroring in vivo early eye development

The paper shows fish-derived organoids rapidly self-organize into retinal tissue, mimicking in vivo eye development, and highlights the impact of cell number and genetics on morphogenesis.