Retromer repletion with AAV9-VPS35 restores endosomal function in the mouse hippocampus
Yasir H. Qureshi, Diego E. Berman, Ronald L. Klein, Vivek M. Patel, Sabrina Simoes, Suvarnambiga Kannan, Rebecca L. Cox, Samuel D. Waksal, Beth Stevens, Gregory A. Petsko, Scott A. Small
This study shows that restoring VPS35 in the hippocampus of mice with chronic neuronal VPS35 depletion rescues APP cleavage and glutamate receptor levels, and reduces glial activation similar to Alzheimer's disease.
Alzheimer s & Dementia · Jul 1, 2019Peer-reviewedNeuroscience