Cryo-EM Structures Reveal Upstream DNA Interactions within the Mitochondrial Transcription Initiation Complex
Rory E. Sharkey, Caitlin Schroeder, Xiangyu Deng, Jamie Smith, Alfredo J. Hernandez, Yang Gao
The paper presents cryo-EM structures of mitochondrial transcription initiation complexes, showing how TFAM and PolRMT interact with upstream DNA to regulate transcription initiation and specificity.
Journal of Biological Chemistry · Sep 29, 2026Peer-reviewedBiochemistry