Xiangyu Deng

The paper presents cryo-EM structures of mitochondrial transcription initiation complexes, showing how TFAM and PolRMT interact with upstream DNA to regulate transcription initiation and specificity.

This study analyzes 595 Salmonella Typhimurium genomes to show that food animal isolates have more open pangenomes and antimicrobial resistance genes, with swine isolates showing the most diversity and plasmid prevalence.

The paper challenges the validation of ZYS-1 as an ADAR1 inhibitor, showing it lacks inhibitory activity in validated assays.

The paper develops a method to identify bacterial pairs through cell-cell binding, enriching for specific genera and revealing dependencies between strains.

This study characterizes ADAR1's RNA editing mechanism through biochemical profiling and structural analysis, revealing sequence and duplex length dependence, disease mutation impacts, and the role of RNA-binding domain 3.

The paper shows that m6A deficiency leads to 7SK RNA activation of the RIG-I/MAVS axis and ZBP1-mediated necroptotic cell death through IFN and rG4 synergies.

The paper identifies that Nextera XT library preparation introduces low GC sequencing bias, affecting O antigen prediction by SeqSero2 in Salmonella genomes.