Alfredo J. Hernandez

The paper presents cryo-EM structures of mitochondrial transcription initiation complexes, showing how TFAM and PolRMT interact with upstream DNA to regulate transcription initiation and specificity.

This study examines how the T7 bacteriophage replisome replicates DNA with CAG and CTG trinucleotide repeats, revealing differences in replication efficiency and product length.

This study shows that pathogenic (A2G3)n repeats in CANVAS stall DNA replication by forming alternative DNA structures like triplexes, while nonpathogenic (A4G)n repeats do not.