Sequence based prediction of cell type specific microRNA binding and mRNA degradation for therapeutic discovery
Bhargav Kanuparthi, Sara E. Pour, Scott D. Findlay, Omar Wagih, Jahir M. Gutierrez, Rory Gao, Jeff A. Wintersinger, Jiun-Nong Lin, Martino Gabra, Emma Bohn, Tammy Lau, Chris Cole, Andrew Jung, Albi Celaj, Fraser Soares, , Brendan J. Frey
This paper introduces REPRESS, a deep learning model that predicts cell-type-specific microRNA binding and mRNA degradation from RNA sequences, outperforming existing methods in multiple tasks.
bioRxiv · May 15, 2025 · PreprintGenomics