Engineering butyrate-producing Lachnospiraceae to treat metabolic disease
Jack H. Arnold, Sandra McClure, Joshua Glazier, Recep Erdem Ahan, Sadiksha Shakya, David Villegas, Tracy Leidan Chen, Jay Fuerte-Stone, Rory McGann, Mark Mimee
This paper engineers Lachnospiraceae bacteria to secrete IL-22, improving glucose homeostasis and reducing liver fat in a mouse model of metabolic disease.
bioRxiv · Nov 8, 2025 · PreprintSynthetic Biology