Author

Joshua Glazier

University of ChicagoORCID 0000-0002-3209-0544Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:metagenomics· 1 Organism:mouse· 1 Assay:proteomics· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

Mark MimeeiD· 3 shared Cassandra E. ThompsoniD· 2 shared David VillegasiD· 2 shared Jay Fuerte-StoneiD· 2 shared Leor S. WeinbergeriD· 2 shared Sandra McClureiD· 2 shared Benjamin MartiniD· 1 shared Elizabeth J. TanneriD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersSynthetic Biology

Mark MimeeORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Programmable genetic control of tumor-colonizing Bifidobacterium longum for intratumoral therapeutic delivery and biocontainment

Jaehyun Lee, Joshua Glazier, Ralph R. Weichselbaum, Mark Mimee

This paper develops a genetic control system for Bifidobacterium longum to regulate its activity in tumors, enabling therapeutic delivery and biocontainment.

bioRxiv · Aug 17, 2026 · PreprintSynthetic Biology

Mining Microbial Transcriptomes to Engineer Cell-Based Bacterial Biosensors in Gut-Resident Bacteroidaceae

Joshua Glazier, David Villegas, Sandra McClure, Joyce Ghali, Jay Fuerte-Stone, Mark Mimee

The paper develops a pipeline to identify environment-responsive promoters in gut-resident Bacteroidaceae by mining transcriptomes and screening biosensors in vivo.

bioRxiv · Aug 11, 2026 · PreprintSynthetic Biology

Engineering butyrate-producing Lachnospiraceae to treat metabolic disease

Jack H. Arnold, Sandra McClure, Joshua Glazier, Recep Erdem Ahan, Sadiksha Shakya, David Villegas, Tracy Leidan Chen, Jay Fuerte-Stone, Rory McGann, Mark Mimee

This paper engineers Lachnospiraceae bacteria to secrete IL-22, improving glucose homeostasis and reducing liver fat in a mouse model of metabolic disease.

bioRxiv · Nov 8, 2025 · PreprintSynthetic Biology

RanDeL-seq: A high-throughput method to map viral cis- and trans-acting elements

Timothy Notton, Joshua Glazier, Victoria R. Saykally, Cassandra E. Thompson, Leor S. Weinberger

RanDeL-seq maps viral cis- and trans-acting elements by generating and screening high-throughput deletion mutants, revealing critical regions in HIV-1 and ZIKV.

mBio · Jan 18, 2021Peer-reviewedSynthetic Biology

Discovery and Engineering of a Therapeutic Interfering Particle (TIP): a combination self-renewing antiviral

Elizabeth J. Tanner, Seungyong Jung, Joshua Glazier, Cassandra E. Thompson, Yuqi Zhou, Benjamin Martin, Hye-In Son, James L. Riley, Leor S. Weinberger

This paper discovers and engineers an HIV-1 Therapeutic Interfering Particle (TIP) that suppresses viral replication and protects CD4+ T cells in humanized mice.

bioRxiv · Oct 30, 2019 · PreprintSynthetic Biology