Recep Erdem Ahan

Developing Anti-EGFR/Anti-HER2 Bifunctional Antibody for Solid Tumors by Protein Engineering

This paper develops a bispecific anti-EGFR/HER2 antibody to enhance antitumor effects by targeting both receptors and improving immune responses.

Engineering butyrate-producing Lachnospiraceae to treat metabolic disease

This paper engineers Lachnospiraceae bacteria to secrete IL-22, improving glucose homeostasis and reducing liver fat in a mouse model of metabolic disease.

A Bacterial Living Therapeutics with Engineered Protein Secretion Circuits To Eliminate Breast Cancer Cells

This study engineers E. coli to secrete a toxin targeting HER2+ breast cancer cells, demonstrating efficient binding and cell killing in vitro.

Synergistic Screening of Peptide-Based Biotechnological Drug Candidates for Neurodegenerative Diseases using Yeast Display and Phage Display

The paper develops a platform combining yeast and phage display to screen peptide therapeutics for neurodegenerative diseases, identifying candidates that inhibit amyloid fibril formation.

A Synthetic Protein Secretion System for Living Bacterial Therapeutics

This paper introduces a protein secretion system for gram-negative bacteria to enable targeted protein delivery for therapeutic applications.

Multiplexed Cell-Based Diagnostic Devices for Detection of Renal Biomarkers Using Genetic Circuits

This study develops two biosensors for detecting urea and uric acid, key renal biomarkers, using genetic circuits and tests their performance in human blood serum.