BioinformaticsbioRxivPreprint
Epigenetically constrained astrocyte states underlie prefrontal cortex vulnerability in Down syndrome associated Alzheimer disease
Chuhanwen Sun, Raina W. Thomas, Cherie A Stringer…·Jiekun Yang
The paper identifies a vulnerable astrocyte state in the prefrontal cortex of Down syndrome-associated Alzheimer's disease through integrated single-nucleus RNA-seq and ATAC-seq analysis.