Jiekun Yang

This study identifies Tex15 as a gene required for maintaining diversity in odorant receptor expression in mouse olfactory neurons.

The paper identifies a vulnerable astrocyte state in the prefrontal cortex of Down syndrome-associated Alzheimer's disease through integrated single-nucleus RNA-seq and ATAC-seq analysis.

STCS reconstructs cell-level gene expression from spatial transcriptomics data, improving accuracy across platforms and tissues.

This study examines how exercise training affects subcutaneous white adipose tissue transcriptomes in individuals with obesity and T2D, finding that exercise reverses detrimental gene expression patterns and correlates with improved metabolic markers.

The paper identifies a mature dendritic cell subtype associated with improved immune response and prognosis in melanoma patients treated with anti-PD-1 checkpoint inhibitors.

This study creates a spatiotemporal transcriptomic atlas of mouse intestinal regeneration following ionizing radiation, revealing transcriptional patterns and mechanisms of epithelial repair.

This study develops a zebrafish model of mucosal melanoma by activating an oncogene and inactivating tumor suppressors, revealing that internal melanocytes give rise to tumors with distinct transcriptional and chromatin features.

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

The paper introduces contextualized network inference to estimate sample-specific transcriptional networks for 7000 tumors, improving accuracy and enabling novel prognostic subtyping.

The paper identifies HIF-2α as a therapeutic target for immune-infiltrated melanomas through stratified analysis of clinical and molecular data.

This study identifies ISL2 as an epigenetically silenced tumor suppressor in pancreatic cancer that regulates metabolism and presents therapeutic vulnerabilities.