Exploring polycyclic scaffolds as adamantane replacements in M2 channel inhibitors of Influenza A virus
Andreea L. Turcu, Rosana Leiva, Chunlong Ma, Kyriakos Georgiou, Jose Manuel Brea, Marı́a Isabel Loza, Cristina Val, Lieve M. J. Naesens, Jun Wang, Antonios Kolocouris, Santiago Vázquez
This study synthesizes and evaluates polycyclic amines as alternatives to adamantane in M2 channel inhibitors, identifying compounds effective against wild-type and mutant M2 channels and showing antiviral activity against human coronavirus 229E.
bioRxiv · Jul 26, 2025 · PreprintPharmacology & Toxicology