Andreea L. Turcu

A brain-penetrant P2X7R antagonist mitigates Alzheimer's disease pathology

This paper identifies UB-ALT-P2, a P2X7R antagonist that reduces Alzheimer's disease pathology in mice by improving memory, reducing amyloid-beta and tau, and decreasing inflammation.

Exploring polycyclic scaffolds as adamantane replacements in M2 channel inhibitors of Influenza A virus

This study synthesizes and evaluates polycyclic amines as alternatives to adamantane in M2 channel inhibitors, identifying compounds effective against wild-type and mutant M2 channels and showing antiviral activity against human coronavirus 229E.

Memantine Inhibits Calcium-Permeable AMPA Receptors

This study shows memantine inhibits calcium-permeable AMPA receptors, revealing a new mechanism distinct from NMDA receptors and suggesting therapeutic potential for neurological disorders.

UB-MBX-46 is a potent and selective antagonist of the human P2X7 receptor developed by structure-based drug design

The paper identifies molecular features of the human P2X7 receptor using cryo-EM structures and designs a potent, selective antagonist, UB-MBX-46, with picomolar potency and high selectivity.