Antonios Kolocouris

This paper identifies UB-ALT-P2, a P2X7R antagonist that reduces Alzheimer's disease pathology in mice by improving memory, reducing amyloid-beta and tau, and decreasing inflammation.

This study synthesizes and evaluates polycyclic amines as alternatives to adamantane in M2 channel inhibitors, identifying compounds effective against wild-type and mutant M2 channels and showing antiviral activity against human coronavirus 229E.

This paper evaluates the anti-parasitic effects of SQ109 and MeSQ109 against Leishmania mexicana and investigates their mechanism of action, including mitochondrial and acidocalcisome targeting.

The paper identifies molecular features of the human P2X7 receptor using cryo-EM structures and designs a potent, selective antagonist, UB-MBX-46, with picomolar potency and high selectivity.

This study evaluates amantadine analogs against influenza A viruses with M2S31N resistance, finding some inhibit viral entry and assembly while being tolerated in mice.

This paper uses molecular dynamics simulations to show that cholesterol stabilizes M2 channel clusters, enhancing membrane curvature and promoting viral budding.