Mitotic transcription ensures ecDNA inheritance through chromosomal tethering
Ashley Nichols, Roshan Norman, Yanyang Chen, Yu-Jin Choi, Josefine Striepen, Eralda Salataj, Eléonore Toufektchan, Richard P. Koche, John Maciejowski
The paper shows that ecDNA inheritance is ensured through mitotic transcription and chromosomal tethering via BRD4 and PVT1, preventing cytosolic mis-segregation and chromosomal integration.
bioRxiv · Feb 12, 2025 · PreprintMolecular Biology