Author

Yanyang Chen

Memorial Sloan Kettering Cancer CenterORCID 0000-0003-4665-9671Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ashley NicholsiD· 2 shared Eléonore ToufektchaniD· 2 shared John MaciejowskiiD· 2 shared Abraham ShimiD· 1 shared Alex KentsisiD· 1 shared Anna E BridgemaniD· 1 shared Anna‐Katerina HadjantonakisiD· 1 shared Benjamin T. JacksoniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMolecular Biology

Ashley NicholsORCID

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3 papers

Recent·Most cited

Molecular BiologyMolecular CellPeer-reviewedMar 1, 2026

ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei

Yanyang Chen, R. M. Norman, Eléonore Toufektchan…·John Maciejowski

The paper identifies BAF as a barrier that restricts TREX1 access to micronuclei, explaining the need for ER-tethering to enable TREX1 entry and suppress cGAS activation.

5 citationstop 2%

humanexperimental assay

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Molecular BiologybioRxivPreprintFeb 12, 2025

Mitotic transcription ensures ecDNA inheritance through chromosomal tethering

Ashley Nichols, Roshan Norman, Yanyang Chen…·John Maciejowski

The paper shows that ecDNA inheritance is ensured through mitotic transcription and chromosomal tethering via BRD4 and PVT1, preventing cytosolic mis-segregation and chromosomal integration.

1 citation

humanDNA methylation

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Developmental BiologyNature MetabolismPeer-reviewedJan 3, 2024

Amino acid intake strategies define pluripotent cell states

Pavlina Krasimirova Todorova, Benjamin T. Jackson, Vidur Garg…·Lydia W.S. Finley

This study shows that mouse embryonic stem cells (ESCs) can proliferate without essential amino acids by taking up and digesting exogenous protein, mimicking pre-implantation embryos.

20 citations

mouseproteomics

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